Selank
Selank is a tuftsin-derived heptapeptide studied for anxiolytic-like, cognitive, immune, and gene-expression effects.
What Selank is
Selank is a synthetic heptapeptide derived from the immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro sequence. Research has examined anxiolytic-like behavior, cognitive endpoints, cytokine signaling, monoamine systems, and gene-expression changes related to GABAergic neurotransmission. Much of the literature comes from Russian research groups and includes both clinical and preclinical designs.
Education content should keep Selank in research-use framing. It is not an FDA-approved drug product, and research-grade Selank is Research Use Only and not for human consumption. Reported ranges below reflect published human or animal study contexts where available and should not be treated as a protocol.
The record for Selank spans both animal work and human trials. Those two kinds of evidence do not carry equal weight, and the amounts below come from different settings.
How it works
Selank is studied as a tuftsin analog with neuroimmune and neuromodulatory effects. Published work links it to GABAergic gene-expression changes, monoamine metabolism, cytokine modulation, and anxiolytic-like behavioral outcomes. Unlike a single-receptor sedative model, Selank appears in the literature as a multi-pathway peptide with immune and CNS dimensions. That makes endpoint selection and comparator choice important in research design.
The research context
Selank is studied by neuropharmacologists, behavioral neuroscience groups, psychopharmacology researchers, and immunology-focused peptide labs. Translational reviewers pay close attention to country of origin, formulation, route, and trial design.
What the research examines
Fields of study, not claims. Investigation is not proof.
How it appears in the literature
How these amounts appear in the literature. Read the study before reading the number.
| Research context | Reported amount | Frequency | Route |
|---|---|---|---|
| Clinical intranasal Selank literature commonly discusses sub-milligram to milligram daily exposure | 900 mcg – 2.7 mg | daily in study protocols | intranasal |
| Rat behavioral research with Selank | 100 mcg – 300 mcg | daily course in animal protocols | intraperitoneal or intranasal in animal studies |
Handling & storage
Lyophilized Selank is commonly stored cold, dry, and protected from light; reconstituted research solutions are generally refrigerated and handled aseptically.
Notes on combined research
Selank is often discussed with Semax, nootropic compounds, or anxiolytic comparators, but combined CNS protocols can obscure whether changes reflect peptide effects, stress adaptation, or comparator pharmacology. Research designs should define behavioral endpoints and avoid converting regional clinical literature into general dosing advice.
Selank questions
Published Selank discussions include intranasal human study contexts and animal mcg/kg work. These are reference values only, not recommendations.
Small research vials are often modeled with 1-2 mL reconstitution volumes. The chosen volume sets concentration for lab calculations.
Daily exposure in the literature depends on route, formulation, and study design. Research-grade Selank is not for human consumption.
A responsible chart should separate human intranasal study references from animal per-kg experiments and clearly label all values as research context.
Behavioral and subjective endpoints in studies are usually assessed over days to weeks, while molecular endpoints can be measured on shorter timelines.
A practical human half-life is not well standardized in the mainstream literature. Effects may be discussed separately from simple plasma persistence.
It can be studied with comparators such as anxiolytic drugs or other peptides, but stacking complicates attribution and is not a use recommendation.
Read the research yourself
All of the below resolve to indexed papers on PubMed. We would rather cite less and cite accurately.
- Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.PubMed
- [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].PubMed
- Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.PubMed