Epitalon
Epitalon is a pineal tetrapeptide studied for telomerase activity, cellular aging markers, and circadian-linked biology.
What Epitalon is
Epitalon, also called Epithalon or AEDG, is a short tetrapeptide with the sequence Ala-Glu-Asp-Gly. Research interest comes from pineal-peptide biology, cellular aging models, telomerase activity, gene expression, circadian regulation, and lifespan experiments in animals and cell systems. The evidence base includes many older and region-specific studies, so careful source reading matters.
Epitalon is not an FDA-approved drug product. Research-grade Epitalon is Research Use Only and is not for human consumption. Reported ranges below are drawn from experimental cell and animal contexts where dosing units can differ substantially from vial-based peptide math.
Epitalon has been studied in human trials, which is not true of most compounds in this library. The figures below come from that work.
How it works
Epitalon is studied for effects on telomerase activation, telomere dynamics, chromatin state, antioxidant systems, and pineal-regulated gene expression. Cell studies report changes in telomerase activity and telomere length, while animal studies examine lifespan markers, tumor incidence, and aging biomarkers. The mechanism is not reducible to one receptor target; it is usually framed through gene regulation and peptide bioregulation hypotheses.
The research context
Epitalon is studied by aging biologists, peptide bioregulation researchers, cell-culture groups, and gerontology-focused pharmacologists. Translational reviewers usually distinguish cell and animal findings from human claims because the clinical evidence is limited and heterogeneous.
What the research examines
Each tag marks a field where this compound appears in research. Appearing in a literature is not the same as working.
How it appears in the literature
What the published work actually used. Reference only, not instructions.
| Research context | Reported amount | Frequency | Route |
|---|---|---|---|
| Human somatic cell studies of Epithalon telomerase activity | 0.01 mcg – 10 mcg | cell-culture exposure | in vitro |
| Animal aging biomarker studies with Epitalon | 0.1 mcg – 1 mcg | course-based animal protocols | animal-study injection routes |
Handling & storage
Lyophilized Epitalon is commonly stored cold, dry, and protected from light; reconstituted research solutions are generally refrigerated and handled aseptically.
Notes on combined research
Epitalon is often discussed with longevity-oriented compounds, NAD+ biology, or mitochondrial peptides, but those combinations can turn a cellular-aging question into an uninterpretable multi-variable protocol. Research designs should define whether the endpoint is telomerase, circadian markers, oxidative stress, or lifespan-model biology before adding other compounds.
Epitalon questions
Published Epitalon work includes cell-culture and animal-study exposures with different units. These are reference values, not personal dosing guidance.
Research vials are often modeled with 1-2 mL reconstitution volumes. The right lab concentration depends on the experiment.
Daily schedules discussed online often compress heterogeneous research into simple cycles. Literature-based content should cite the model, route, and endpoint.
A responsible chart should separate in vitro concentration data, animal exposure, and vial concentration math rather than presenting one universal chart.
Cellular endpoints such as gene expression can be measured over short lab windows, while aging-model outcomes require longer study designs.
A practical human half-life is not well established in mainstream sources. Research often focuses on downstream cellular markers.
It can be studied alongside other aging-biology variables, but stacking can make telomerase, redox, and circadian findings hard to attribute.
Read the research yourself
Each citation was checked against PubMed before it went on this page. If we cannot link it, we do not claim it.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.PubMed
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.PubMed
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.PubMed